This study evaluates quetiapine as an adjuvant therapy for triple-negative breast cancer, showing it reduces clonogenicity, promotes apoptosis, and impairs DNA repair and migration.

Radiation Research · Apr 23, 2026Peer-reviewedCancer Biology

Radiation-Induced Cellular Plasticity: A Strategy for Combatting Glioblastoma

Ling He, Daria J. Azizad, Kruttika Bhat, Angeliki Ioannidis, Carter J. Hoffmann, Evelyn Arambula, Mansoureh Eghbali, Aparna Bhaduri, Harley I. Kornblum, Frank Pajonk

This study shows that combining radiation with forskolin induces a differentiation-like state in glioma cells, reducing proliferation and extending survival in mouse models.

Proceedings of the National Academy of Sciences · Feb 26, 2025Peer-reviewedCancer Biology

Targeting Innate Immune Signaling in Glioma-Initiating Cells Impairs Self-Renewal and Radiation-Induced Cellular Plasticity

Anjelica M. Cardenas, Linda Azizi, Angeliki Diotima Ioannidis, Kruttika Bhat, Ling He, Mahya Mohammadi, Frank Pajonk

This study investigates how DAMPs influence radiation-induced plasticity in glioma-initiating cells through innate immune signaling pathways.

bioRxiv · Dec 13, 2024 · PreprintCancer Biology

Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

Ling He, Angeliki Diotima Ioannidis, Evelyn Arambula, Carter J. Hoffman, Purva Joshi, Anoushka Kathiravan, Julian P. Whitelegge, Linda M. Liau, Harley I. Kornblum, Frank Pajonk

This study shows that activation of the mevalonate pathway and Rac-1 in glioblastoma cells after anti-cancer treatments promotes recurrence, and statins combined with radiation improve survival in mouse models.

Cancer Research Communications · Jun 5, 2024Peer-reviewedNeuroscience

Effects of Dopamine Receptor Antagonists and Radiation on Mouse Neural Stem/Progenitor Cells

Ling He, Kruttika Bhat, Angeliki Diotima Ioannidis, Frank Pajonk

This study shows dopamine receptor antagonists have sex-dependent effects on neural stem/progenitor cells, potentially reducing radiation-induced cognitive decline in glioblastoma treatment.

bioRxiv · Jan 18, 2023Neuroscience

Synergistic Effects of the DRD2/3 Antagonist ONC201 and Radiation in Glioblastoma

Ling He, Kruttika Bhat, Angeliki Diotima Ioannidis, Le Zhang, Nhan T. Nguyen, Joshua E. Allen, Phioanh Leia Nghiemphu, Timothy Francis Cloughesy, Linda M. Liau, Harley I. Kornblum, Frank Pajonk

This paper shows that combining ONC201 with radiation improves GBM treatment efficacy by targeting glioma-initiating cells in vitro and in vivo without increased toxicity.

Radiotherapy and Oncology · Jun 5, 2021Peer-reviewedNeuroscience

Combined Treatment with Dopamine Receptor Antagonists and Radiation Creates a Metabolic Vulnerability in Mouse Models of Glioblastoma

Kruttika Bhat, Mohammad Saki, Fei Cheng, Ling He, Le Zhang, Angeliki Diotima Ioannidis, David A. Nathanson, Jonathan Tsang, Steven J. Bensinger, Phioanh Leia Nghiemphu, Timothy Francis Cloughesy, Linda M. Liau, Harley I. Kornblum, Frank Pajonk

This study shows that combining quetiapine, atorvastatin, and radiation extends survival in glioblastoma mouse models by exploiting a metabolic vulnerability.

JNCI Journal of the National Cancer Institute · Feb 3, 2021Peer-reviewedNeuroscience

1--4-phenylpiperazine Treatment After Brain Irradiation Preserves Cognitive Function in Mice

Kruttika Bhat, Paul Medina, Ling He, Le Zhang, Mohammad Saki, Angeliki Diotima Ioannidis, Nhan T. Nguyen, Sirajbir S. Sodhi, David Sung, Clara E. Magyar, Linda M. Liau, Harley I. Kornblum, Frank Pajonk

This paper shows that Compound #5 reduces radiation-induced cognitive decline in mice without affecting tumor growth.

Neuro-Oncology · Apr 13, 2020Peer-reviewedNeuroscience