Author

Andreas O. Mieland

University Medical Center of the Johannes Gutenberg University MainzORCID 0000-0002-8672-0708Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Caroline L. AlvaresiD· 1 shared Christoph HieberiD· 1 shared Ina OehmeiD· 1 shared Joanna ZabkiewicziD· 1 shared Matthias BrosiD· 1 shared Matthias Schmidt· 1 shared Melisa HaliloviciD· 1 shared Michelle LazenbyiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Caroline L. AlvaresORCID

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Author profile →

1 paper

Recent·Most cited

Rapid proteasomal degradation of mutant feline McDonough sarcoma-like tyrosine kinase-3 overcomes tyrosine kinase inhibitor resistance of acute myeloid leukemia cells

Melisa Halilovic, Mohamed Abdalla M. Abdelsalam, Andreas O. Mieland, Sarah Neuroth, Ramy Ashry, Joanna Zabkiewicz, Michelle Lazenby, Caroline L. Alvares, Matthias Schmidt, Walburgis Brenner, Sara Najafi, Ina Oehme, Christoph Hieber, Yanira Zeyn, Matthias Bros, , Oliver Holger Krämer

This study develops MA191, a PROTAC degrader of FLT3-ITD, which overcomes resistance in AML cells by rapidly degrading the mutant protein and shows efficacy in vivo.

bioRxiv · Jun 20, 2025 · PreprintPharmacology & Toxicology