Author

Oliver Holger Krämer

University Medical Center of the Johannes Gutenberg University MainzORCID 0000-0003-3973-045XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Al‐Hassan M. MustafaiD· 1 shared Andreas O. MielandiD· 1 shared Caroline L. AlvaresiD· 1 shared Christoph HieberiD· 1 shared Günter SchneideriD· 1 shared Ina OehmeiD· 1 shared Joanna ZabkiewicziD· 1 shared Jörg HartkampiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Al‐Hassan M. MustafaORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 16, 2025

The Deacetylases HDAC1 and HDAC2 Safeguard BCR-ABL-positive Cells from Replication Stress-Induced Apoptosis via the Nuclear to Mitochondrial p73-NOXA Axis

Al‐Hassan M. Mustafa, Miriam Pons, Nisintha Mahendrarajah…·Oliver Holger Krämer

This study shows HDAC1 and HDAC2 protect BCR-ABL-positive CML cells from replication stress-induced apoptosis via the p73-NOXA axis.

DOI 10.64898/2025.12.13.694110

humanbulk RNA-seq

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Pharmacology & ToxicologybioRxivPreprintJun 20, 2025

Rapid proteasomal degradation of mutant feline McDonough sarcoma-like tyrosine kinase-3 overcomes tyrosine kinase inhibitor resistance of acute myeloid leukemia cells

Melisa Halilovic, Mohamed Abdalla M. Abdelsalam, Andreas O. Mieland…·Oliver Holger Krämer

This study develops MA191, a PROTAC degrader of FLT3-ITD, which overcomes resistance in AML cells by rapidly degrading the mutant protein and shows efficacy in vivo.

2 citations

humanproteomics

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