Ranit Dutta

This paper introduces tPolyTACs, a covalent enzyme-responsive platform for extracellular protein degradation, showing enhanced selectivity and efficiency by using phosphatase-cleavable substrates to trigger lysosomal targeting.

This study shows that slower, sustained drug release from hydrogels improves therapeutic outcomes in post-traumatic osteoarthritis compared to faster release.

The paper demonstrates that multivalent ligand-protein interactions using PolyTACs can degrade transmembrane proteins without lysosome-targeting receptors.