Author

Badal Singh

University of Massachusetts AmherstORCID 0009-0001-5028-7017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 1

Frequent Co-Authors

Ranit DuttaiD· 2 shared S. ThayumanavaniD· 2 shared Adam Tajdi· 1 shared Allison Lomeli· 1 shared Amelia Talluri· 1 shared Aniket Majee· 1 shared Anirudh DevarajaniD· 1 shared Prachi GuptaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Ranit DuttaORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 7, 2026

Enzyme Activation of Triggerable Polymeric Lysosome Targeting Chimeras

Badal Singh, Priyanath Das, Aniket Majee…·S. Thayumanavan

This paper introduces tPolyTACs, a covalent enzyme-responsive platform for extracellular protein degradation, showing enhanced selectivity and efficiency by using phosphatase-cleavable substrates to trigger lysosomal targeting.

DOI 10.64898/2026.09.03.749226

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BioengineeringbioRxivPreprintMay 6, 2025

Multivalent Ligand-Protein Interactions Using Polymeric Lysosome-Targeting Chimeras (PolyTACs) Leads to Lysosome-Targeting Receptor-Independent Degradation of Transmembrane Proteins

Ranit Dutta, Yasin Alp, Prachi Gupta…·S. Thayumanavan

The paper demonstrates that multivalent ligand-protein interactions using PolyTACs can degrade transmembrane proteins without lysosome-targeting receptors.

1 citation

protein structureexperimental assay

𝕏 PostBluesky