Author

Sina Maletti

University of BernORCID 0000-0002-8678-0321Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrej BenjakiD· 2 shared Dilara AkhoundovaiD· 2 shared Lea LinggiD· 2 shared Marika LehneriD· 2 shared Mark A. RubiniD· 2 shared Muriel JaquetiD· 2 shared Paola FrancicaiD· 2 shared Phillip ThiengeriD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Andrej BenjakORCID

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2 papers

Recent·Most cited

Cancer Biologynpj Precision OncologyPeer-reviewedJul 11, 2026

Aurora kinase A is a synthetic lethal target in FANCA-deficient cancers

Dilara Akhoundova, Martín González Fernández, Aavash Baral…·Mark A. Rubin

The paper identifies Aurora kinase A as a synthetic lethal target in FANCA-deficient cancers and shows AURKA inhibition induces chromosomal instability and G2/M arrest in these cells.

DOI 10.1038/s41698-026-01596-7

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 13, 2025

Blocking Minor Intron Splicing Disrupts DNA Repair and Overcomes Therapy Resistance in Prostate and Breast Cancer

Anke Augspach, Paola Francica, Kaitlin N. Girardini…·Mark A. Rubin

This study shows that targeting the minor spliceosome, specifically U6atac snRNA, disrupts DNA repair and overcomes therapy resistance in prostate and breast cancers.

DOI 10.64898/2025.12.10.693392

humanDNA methylation

𝕏 PostBluesky