Author

Lea Lingg

University of BernORCID 0000-0002-9964-8397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Dilara AkhoundovaiD· 3 shared Paola FrancicaiD· 3 shared Simone de BrotiD· 3 shared Sven RottenbergiD· 3 shared Andrej BenjakiD· 2 shared Erik VassellaiD· 2 shared Marika LehneriD· 2 shared Mark A. RubiniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Dilara AkhoundovaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Aurora kinase A is a synthetic lethal target in FANCA-deficient cancers

Dilara Akhoundova, Martín González Fernández, Aavash Baral, Andrej Benjak, Carmen Perry, Dinda Shezaria Hardy Lubis, Ladina Hörtensteiner, Saskia Hussung, Lea Lingg, Sina Maletti, Aino Paasinen-Sohns, Marika Lehner, Bastian Dislich, Erik Vassella, Simone de Brot, , Mark A. Rubin

The paper identifies Aurora kinase A as a synthetic lethal target in FANCA-deficient cancers and shows AURKA inhibition induces chromosomal instability and G2/M arrest in these cells.

npj Precision Oncology · Jul 11, 2026Peer-reviewedCancer Biology

Blocking Minor Intron Splicing Disrupts DNA Repair and Overcomes Therapy Resistance in Prostate and Breast Cancer

Anke Augspach, Paola Francica, Kaitlin N. Girardini, Muriel Jaquet, Marika Lehner, Antonio Rodríguez-Calero, Charlotte Komarek, Martín González-Fernández, Hannah Williams, Xiaoyue Deng, Lea Lingg, Cristina Zivko, Vera Fuchs, Seynabou Diop, Sina Maletti, , Mark A. Rubin

This study shows that targeting the minor spliceosome, specifically U6atac snRNA, disrupts DNA repair and overcomes therapy resistance in prostate and breast cancers.

bioRxiv · Dec 13, 2025 · PreprintCancer Biology

TAOK1 regulates chemo- and radiosensitivity in BRCA1/2-deficient tumors

Lea Lingg, Merve Mutlu, Arunasalam Naguleswaran, Ismar Klebic, Ewa Gogola, Dilara Akhoundova, Pascale Martine Schürch, Raviprasad Kuthethur, Carmen Fonseca, Simone de Brot, Marieke Everts, Martín González Fernández, Saskia Hussung, Erik Vassella, Marcel A.T.M. van Vugt, , Paola Francica

This study identifies TAOK1 as a regulator of replication fork stability in BRCA1/2-deficient tumors, showing it enhances sensitivity to PARPi and IR through PCNA and ISG15 interactions.

bioRxiv · Oct 14, 2025 · PreprintCancer Biology