NeuroscienceScience AdvancesPeer-reviewed
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons causes non-motor parkinsonian symptoms
Wei‐Hua Chiu, Lora Kovacheva, Ruth E. Musgrove…·Joshua A. Goldberg
This study identifies a Kv4 channelopathy in mouse vagal motoneurons caused by α-synuclein overexpression, leading to impaired gastrointestinal motility as a non-motor prodromal symptom of Parkinson's disease.
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