Maniteja Arava

This study uses single-cell spatial transcriptomics on cryopreserved human lung slices to identify molecular features of pulmonary fibrosis niches and their associated signaling pathways.

The paper investigates lineage-specific coordination of X-chromosome inactivation and active-X upregulation in female cells across different developmental contexts and identifies UTF1 as a mediator of X-upregulation erasure in some lineages.

The paper investigates how Xist loss affects X-linked gene reactivation in XEN and EpiSC, showing that chromatin states determine gene silencing stability.

The paper uses single-cell analysis to show partial reactivation of the inactive X-chromosome in naive human pluripotent stem cells, challenging the notion of chromosome-wide dampening.