Cancer BiologyNaturePeer-reviewed
Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance
Konstantin Okonechnikov, Piyush K. Joshi, Verena Körber…·Stefan Michael Pfister
The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.