Katharina Johanna Weber

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

The paper uses single-cell sequencing and spatial transcriptomics to compare immune responses in leptomeningeal disease with other CNS disorders, identifying disease-specific immune environments and progression mechanisms.

The paper identifies an epigenetic neural signature in glioblastoma that correlates with poor prognosis and therapeutic vulnerability.