Claus Scheidereit

A computational model of the DNA damage-induced IKK/ NF-κB pathway reveals a critical dependence on irradiation dose and PARP-1

The paper develops a computational model of the DNA damage-induced IKK/NF-κB pathway to analyze how irradiation dose and PARP-1 influence pathway activation.

Autophagy limits inflammatory gene expression through targeting of nuclear p65/RelA by LC3 and p62 for lysosomal degradation

This study identifies a mechanism by which autophagy regulates NF-κB-driven inflammation through lysosomal degradation of nuclear p65 via LC3 and p62.

TSG101 Associates with PARP1 and is Essential for PARylation and DNA Damage-induced NF-κB Activation

This study identifies TSG101 as essential for PARylation and DNA damage-induced NF-κB activation, showing its role in DNA repair and apoptosis protection.

A quantitative modular modeling approach reveals the consequences of different A20 feedback implementations for the NF-kB signaling dynamics

The paper compares different A20 feedback implementations in NF-κB signaling models to determine their impact on dynamics, finding that one model aligns with experimental data.

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.