Structures of MyD88 and its oncogenic mutant reveal DNA binding with implications for cytosolic DNA sensing
Pietro Fontana, Ahmet Buğra Tufan, Patrick Günther, Elena Goldberg, Sebastian Dörfler, Setu M. Vora, Leo Schirokauer, João A. Paulo, Hyung Suk Oh, Steven P. Gygi, David M. Knipe, Hao Wu
This study reveals the structure of MyD88 and its oncogenic mutant, showing direct DNA binding and its role in innate immune responses.
bioRxiv · Oct 29, 2026 · PreprintImmunology