Replication-induced DNA secondary structures drive fork uncoupling and breakage
Sophie L. Williams, Corella S. Casas-Delucchi, Federica Raguseo, Dilek Guneri, Yunxuan Li, Masashi Minamino, Emma E Fletcher, Joseph T.P. Yeeles, Ulrich F. Keyser, Zoë A. E. Waller, Marco Di Antonio, Gideon Coster
This study shows that DNA secondary structures like G4s and iMs cause replication fork arrest and breakage, and that Pif1 helicase is required to resolve stalled forks.
The EMBO Journal · Oct 2, 2023Peer-reviewedMolecular Biology