Author

Emma E Fletcher

MRC Laboratory of Molecular BiologyORCID 0000-0002-0792-5212Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:DNA methylation· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1 Organism:yeast· 1

Frequent Co-Authors

Joseph T.P. YeelesiD· 2 shared Corella S. Casas-DelucchiiD· 1 shared Dilek GuneriiD· 1 shared Ella Taylor-CrossiD· 1 shared Federica RaguseoiD· 1 shared Gideon CosteriD· 1 shared Isaac X R ChaniD· 1 shared Johann J. RoskeiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Joseph T.P. YeelesORCID

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2 papers

Recent·Most cited

MCM10 targets CMG dimers via a conserved mechanism for synchronized helicase activation

Ella Taylor-Cross, Morgan L. Jones, Johann J. Roske, Emma E Fletcher, Isaac X R Chan, Joseph T.P. Yeeles

The paper reveals a conserved mechanism by which MCM10 targets CMG dimers to synchronize helicase activation in eukaryotes through structural analysis of yeast and human complexes.

bioRxiv · May 16, 2026 · PreprintMolecular Biology

Replication-induced DNA secondary structures drive fork uncoupling and breakage

Sophie L. Williams, Corella S. Casas-Delucchi, Federica Raguseo, Dilek Guneri, Yunxuan Li, Masashi Minamino, Emma E Fletcher, Joseph T.P. Yeeles, Ulrich F. Keyser, Zoë A. E. Waller, Marco Di Antonio, Gideon Coster

This study shows that DNA secondary structures like G4s and iMs cause replication fork arrest and breakage, and that Pif1 helicase is required to resolve stalled forks.

The EMBO Journal · Oct 2, 2023Peer-reviewedMolecular Biology