Marco Di Antonio

The paper shows that increased 4R Tau RNA contributes to motor neuron degeneration in ALS by reducing viability and that targeting this RNA could be therapeutic.

This paper introduces ATENA, a method using chemically modified CRISPR-Cas9 to target specific G-quadruplexes and i-motifs, showing ligand-dependent transcriptional changes in c-MYC.

This study maps DNA G-quadruplexes in Trypanosoma brucei, showing enrichment in coding regions and functional impact of G4-stabilizing ligands on gene expression.

This study identifies G-quadruplex structures as regulators of long-range transcriptional reprogramming in drug-resistant ovarian cancer, showing their role in promoting resistance and potential as therapeutic targets.

This paper introduces a platform for engineering synthetic RNA condensates that can form programmable organelles with controlled properties.

This study shows that DNA secondary structures like G4s and iMs cause replication fork arrest and breakage, and that Pif1 helicase is required to resolve stalled forks.