Thomas C. Boothby

The paper identifies a molecular grammar that predicts environmental sensitivity in intrinsically disordered protein regions using sequence features and experimental validation.

This study examines how drying conditions, storage duration, and vitrified properties affect the stability of DNA, RNA, and enzymes in trehalose systems, finding that enzyme protection correlates with initial glass transition temperature but deteriorates with aging.

This study examines how four Arabidopsis LEA proteins respond structurally and functionally to environmental changes, revealing distinct protective mechanisms under desiccation.

This study identifies FLOE1 as a regulator of water content and cytoplasmic viscosity in Arabidopsis embryos, linking molecular water control to cellular physical properties.

This study shows LEA_4 motifs protect an enzyme during desiccation, with enhanced protection when combined with synergistic cosolutes.

The paper identifies protein surface chemistry as a determinant of desiccation tolerance and shows that modifying surface amino acids can confer tolerance to otherwise sensitive proteins.

This study investigates how disordered proteins interact with endogenous cosolutes during drying to enhance desiccation protection across different organisms.