Author

Nourdine Chakouri

Columbia UniversityORCID 0000-0002-8809-8684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Aaron Rodriques· 1 shared Alexander N. KatchmaniD· 1 shared Bence HegyiiD· 1 shared Bi-Xing Chen· 1 shared Christopher D. MakinsoniD· 1 shared Donald M. BersiD· 1 shared Elaine Y. WaniD· 1 shared Erin R. CulleniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Aaron Rodriques

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1 paper

Recent·Most cited

De novo Design of a Peptide Modulator to Reverse Sodium Channel Dysfunction Linked to Cardiac Arrhythmias and Epilepsy

Ryan W. Mahling, Bence Hegyi, Erin R. Cullen, Timothy M. Cho, Aaron Rodriques, Lucile Fossier, Mohamad Yehya, Lin Yang, Bi-Xing Chen, Alexander N. Katchman, Nourdine Chakouri, Ruiping Ji, Elaine Y. Wan, Jared Kushner, Steven O. Marx, , Manu Ben Johny

This study designs a de novo peptide modulator, ELIXIR, that inhibits pathogenic late sodium current in NaV channels, reversing dysfunction in cardiac arrhythmias and epilepsy models.

Cell · Aug 18, 2025Peer-reviewedBiophysics