Huishi Toh

This study examines how different lighting conditions affect circadian rhythms and physiology in diurnal Nile grass rats, finding that daylight-equivalent lighting produces stronger circadian entrainment and better physiological outcomes than fluorescent lighting.

This paper links maternal high-fiber diet to reduced offspring type 2 diabetes risk through multi-tissue transcriptomic and metabolomic analyses in Nile rats, identifying ASNSD1 as a key gene involved.

This study integrates GWAS with eQTL and pQTL analyses to identify functionally relevant variants and molecular mechanisms in type 2 diabetes.

This paper develops an AI model using fluorescein angiography images to detect pre-symptomatic diabetic retinopathy in Nile rats with high accuracy and identifies inflammation-related gene markers associated with early DR pathogenesis.

The paper demonstrates successful CRISPR genome editing in the Nile grass rat, a diurnal rodent, establishing methods for reproductive and genetic manipulation.

The paper develops CRSP, a pipeline for RNA-seq analysis in species without a sequenced genome or reference transcripts, and applies it to generate a comprehensive Nile grass rat transcriptomic atlas.

This paper presents a haplotype-resolved genome assembly of the Nile rat, revealing unique genomic features relevant to type 2 diabetes and metabolic dysfunctions.

This study shows that a maternal high fiber diet reduces the risk of diet-induced diabetes in offspring, even when offspring are exposed to a diabetogenic diet later in life.