Stabilization of the open conformation of Insulin-Regulated Aminopeptidase by a novel substrate-selective small molecule inhibitor
Anastasia Mpakali, Galateia Georgaki, Alberto Buson, Alison D. Findlay, Jonathan S. Foot, François‐Xavier Mauvais, Peter Van Endert, Petros Giastas, Dieter W. Hamprecht, Efstratios Stratikos
This paper identifies a nanomolar inhibitor of IRAP that stabilizes its open conformation, revealing a conformation-specific mechanism of action and insights into its catalytic cycle.
Protein Science · Aug 21, 2024Peer-reviewedBiochemistry