Molecular BiologySciencePeer-reviewed
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome
Pramod R. Bhatt, Alain Scaiola, Gary Loughran…·Nenad Ban
This study presents the cryo-EM structure of the mammalian ribosome during SARS-CoV-2 RNA translation, revealing the pseudoknot structure that facilitates ribosomal frameshifting and identifies a compound that inhibits viral replication.
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