Alain Scaiola

This study presents the cryo-EM structure of the mammalian ribosome during SARS-CoV-2 RNA translation, revealing the pseudoknot structure that facilitates ribosomal frameshifting and identifies a compound that inhibits viral replication.

This study identifies mitochondrial translation termination mechanisms using single particle cryo-EM, showing how release factors and peptidyl-tRNA hydrolases function in releasing and rescuing stalled ribosomes.

This study shows SARS-CoV-2 Nsp1 binds to the 40S ribosomal subunit to inhibit translation by blocking mRNA entry, while viral mRNA enhances its own translation.

The paper determines the structure of a cytoplasmic pre-40S ribosomal subunit using cryo-EM, revealing conformational changes and the roles of assembly factors in its maturation.