Jeffrey W. Bode

The paper develops a macrocyclic peptide WJL-63 with high ACE2-binding affinity and characterizes its structure and potential for imaging applications.

This paper develops and evaluates radiofluorinated derivatives of MLN-4760 for PET imaging of ACE2, finding that [18F]F-MLN-4760 shows superior binding affinity and yield.

This paper introduces LUX-MS, a light-triggered optoproteomic technology to map surfaceome receptor interactions and nanoscale organization, revealing insights into intercellular signaling and drug action.

This study presents the cryo-EM structure of the mammalian ribosome during SARS-CoV-2 RNA translation, revealing the pseudoknot structure that facilitates ribosomal frameshifting and identifies a compound that inhibits viral replication.