Author

Rodolfo Bortolozo Serafim

Boston Children's HospitalORCID 0000-0002-8884-2303Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Rani E. GeorgeiD· 2 shared Allen Thayakumar BasanthakumariD· 1 shared Ashleigh MeyeriD· 1 shared Audrey TailloniD· 1 shared Bandana Sharma· 1 shared Björn HäupliD· 1 shared Cibele Campos CardosoiD· 1 shared Constanze SchneideriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Rani E. GeorgeORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 28, 2025

Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents

Constanze Schneider, Gabriela Alexe, Lucy A. Merickel…·Kimberly Stegmaier

The paper identifies USP48 as a regulator of chromatin stability and DNA damage response to hypomethylating agents, showing its loss increases susceptibility to these drugs in AML.

DOI 10.1101/2025.07.28.666975

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 1, 2025

CDK12/13 inhibition disrupts nucleolar morphology and promotes aberrant expression of IGS transcripts

Rodolfo Bortolozo Serafim, Marina P. Volegova, Matt L. Harlow…·Rani E. George

This study shows CDK12/13 inhibition disrupts nucleolar structure and causes aberrant IGS rRNA transcript expression due to impaired processing and degradation.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky