Author

Tamar Skaist Mehlman

The Graduate Center, CUNYORCID 0000-0002-8896-1628Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

D. A. KeedyiD· 2 shared Ali EbrahimiD· 1 shared Aliki PerdikariiD· 1 shared Blake T. RileyiD· 1 shared Dinesh Singh ShahiD· 1 shared Elana HenningiD· 1 shared Helen Mary GinniD· 1 shared I. Sadaf FarooqiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

D. A. KeedyORCID

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2 papers

Recent·Most cited

BiophysicsJournal of Biological ChemistryPeer-reviewedOct 23, 2025

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy

Aliki Perdikari, Virgil A. Woods, Ali Ebrahim…·D. A. Keedy

The paper identifies functional PTP1B variants in thin individuals and uses structural biology to reveal allosteric sites for obesity drug development.

8 citations

humanprotein structure

𝕏 PostBluesky

BiophysicsStructurePeer-reviewedJun 10, 2024

An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data

Tamar Skaist Mehlman, Helen Mary Ginn, D. A. Keedy

The paper reanalyzes crystallographic data to identify new ligand-bound states of PTP1B, revealing hidden binding sites and allosteric effects.

16 citations

structural biologystatistical model

𝕏 PostBluesky