D. A. Keedy

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy

The paper identifies functional PTP1B variants in thin individuals and uses structural biology to reveal allosteric sites for obesity drug development.

Three STEPs forward: A trio of unexpected structures of PTPN5

This study presents three new crystal structures of STEP (PTPN5) revealing unexpected conformational features and ligand binding events that provide insights for structure-based drug design.

Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models

The paper develops RINFAIRE to analyze multiconformer models of PTPs, revealing shared and unique allosteric networks and validating their functional impact through mutations.

Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

This paper shows that Grb2 binding to PTP1B allosterically enhances its catalytic activity through structural changes, revealing a new regulatory mechanism for PTP1B in cell signaling.