Sylvia Fitting

Preserved Barrier Integrity and Altered Immune Profiles in Chronic Cannabis Users: Potential Roles of Δ9-Tetrahydrocannabinol

This study shows chronic cannabis use strengthens gut barrier integrity but disrupts systemic immune homeostasis through cytokine dysregulation.

Cocaine-Enriched Oral Streptococcus parasanguinis Promotes Neuroimmune Dysfunction and Memory Impairment

This study shows that cocaine promotes growth of Streptococcus parasanguinis, which leads to neuroinflammation and memory impairment in mice without bacterial translocation.

Cannabis-enriched oral Actinomyces induces anxiety-like behavior via impairing mitochondria and GABA signaling

This study shows that oral Actinomyces species from cannabis users induce anxiety-like behavior in mice through mitochondrial dysfunction and reduced GABAergic signaling.

Pilot study characterizing oral-to-blood microbial DNA translocation in individuals with current cocaine use disorder

This study shows that cocaine use disorder is associated with oral microbial dysbiosis and selective microbial translocation from saliva to blood.

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

This study evaluates the effects of ZCZ011, a CB1R PAM, on behavior and the endocannabinoid system in HIV-1 Tat transgenic mice, showing sex- and genotype-dependent outcomes.