trans-Translation inhibitors that kill M. tuberculosis and pathogenic Non-tuberculous Mycobacteria have a dual mechanism of action
Akanksha Varshney, Ziyi Jia, Gebremichal Gebretsadik, Narendran G-Dayanandan, Terry L. Bowlin, Michelle M. Butler, Anthony D. Baughn, Kenneth C. Keiler
The paper identifies acylaminooxadiazole derivatives that kill mycobacteria by inhibiting trans-translation and disrupting iron homeostasis.
bioRxiv · Jan 22, 2026 · PreprintMicrobiology