Kenneth C. Keiler

The paper uses a simulation model to show how ribosome structure and molecular sterics guide tmRNA translocation during trans-translation.

This paper characterizes SRLase1, an RNase toxin that cleaves the sarcin-ricin loop of 23S rRNA by repurposing EF-Tu, revealing a new mechanism of ribosome inhibition.

This study identifies bL27's role in preventing tmRNA from interfering with protein synthesis during trans-translation in bacteria.

The paper shows that blocked transcription-translation complexes in bacteria are rescued by transcript release and trans-translation, allowing all components to be released.

The paper identifies acylaminooxadiazole derivatives that kill mycobacteria by inhibiting trans-translation and disrupting iron homeostasis.

This study identifies KKL-1005 as a trans-translation inhibitor that targets ribosomal protein bL12 in Mycobacterium tuberculosis, showing it specifically disrupts the trans-translation pathway.

The paper shows that MBX-4132, a trans-translation inhibitor, kills Mycobacterium tuberculosis and non-tuberculous mycobacteria, with zinc enhancing its activity and iron reducing it.

This paper shows that trans-translation inhibitors KKL-40 and KKL-55 synergize with copper ions to enhance antibacterial activity against B. subtilis by causing rapid translation stalling and preventing copper toxicity response.