Author
The University of Texas at AustinORCID 0009-0007-4524-3523Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Julia Takuno Hespanhol, Taylor M Blackburn, Kristi Pham…·Ethel Bayer‐Santos
This paper characterizes SRLase1, an RNase toxin that cleaves the sarcin-ricin loop of 23S rRNA by repurposing EF-Tu, revealing a new mechanism of ribosome inhibition.
Akanksha Varshney, Ziyi Jia, Gebremichal Gebretsadik…·Kenneth C. Keiler
The paper identifies acylaminooxadiazole derivatives that kill mycobacteria by inhibiting trans-translation and disrupting iron homeostasis.
Akanksha Varshney, John N. Alumasa, Amber Miller, Kenneth C. Keiler
This study identifies KKL-1005 as a trans-translation inhibitor that targets ribosomal protein bL12 in Mycobacterium tuberculosis, showing it specifically disrupts the trans-translation pathway.
Akanksha Varshney, Ziyi Jia, Michael D. Howe…·Anthony D. Baughn
The paper shows that MBX-4132, a trans-translation inhibitor, kills Mycobacterium tuberculosis and non-tuberculous mycobacteria, with zinc enhancing its activity and iron reducing it.