Author

Sophia M. Hakam

University of California, DavisORCID 0009-0006-1465-6571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Animal Behavior & Cognition· 1 Cell Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:contrastive learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Dag H. YasuiiD· 3 shared Janine M. LaSalleiD· 3 shared Kari E. NeieriD· 2 shared Osman SharifiiD· 2 shared Ana Paula ArrudaiD· 1 shared Aron Judd P. MendiolaiD· 1 shared Barbara A. CohniD· 1 shared Callum George DonnellyiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersAnimal Behavior & Cognition

Dag H. YasuiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 23, 2026

Ca2+ influx through ER-plasma membrane contacts is required for brown fat thermogenesis and metabolic health

J Zhou, Cansu Doğan, Leonardo Luís Artico…·Ana Paula Arruda

This study identifies ER-PM contacts and STIM-mediated SOCE as essential for brown fat thermogenesis and metabolic health during cold exposure.

DOI 10.64898/2026.03.20.712802

mouseexperimental assay

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Animal Behavior & CognitionbioRxivPreprintMay 1, 2025

Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment

Aron Judd P. Mendiola, Jennifer M. Rutkowsky, Kari E. Neier…·Janine M. LaSalle

The paper examines how Snord116 genotype interacts with light and sex to influence metabolism, behavior, and imprinted gene networks in mice after circadian entrainment.

DOI 10.1101/2025.05.01.651733

mousebulk RNA-seq

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GenomicsBiology of Sex DifferencesPeer-reviewedApr 30, 2025

Sex-specific DNA methylation signatures of autism spectrum disorder in newborn blood

Julia S. Mouat, Nickilou Y. Krigbaum, Sophia M. Hakam…·Janine M. LaSalle

This study identifies sex-specific DNA methylation signatures of autism spectrum disorder in newborn blood, showing replication and enrichment for ASD-risk genes and neurodevelopmental processes.

9 citationstop 4%

humanDNA methylation

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GeneticsCommunications BiologyPeer-reviewedOct 9, 2024

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression

Osman Sharifi, Viktoria Haghani, Kari E. Neier…·Janine M. LaSalle

The paper identifies sex-specific transcriptomic changes in a mouse model of Rett syndrome, showing more differentially expressed genes in females and non-cell-autonomous effects.

16 citationstop 5%

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