Rod C. Scott

Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

This paper identifies novel epilepsy modifier genes in mice through meta-analysis of GWAS data and functional network analysis, highlighting genes involved in neurodevelopmental processes not targeted by current therapies.

Normalization of Prefrontal Network Dynamics Prevents Cognitive Impairments After Developmental Insult

This study shows that developmental insults impair mPFC network dynamics, and ACTH treatment prevents these impairments, preserving cognitive function through restored network organization.

Melanocortin 4 Receptor-Dependent Mechanism of ACTH in Preventing Anxiety-Like Behaviors and Normalizing Astrocyte Proteins After Early Life Seizures

This study shows ACTH prevents anxiety-like behaviors and normalizes astrocyte proteins after early life seizures via MC4R activation in neurons and astrocytes.

Disrupted Hippocampal-Prefrontal Networks In A Rat Model Of Fragile X Syndrome: A Study Linking Neural Dynamics To Autism-Like Behavioral Impairments

This study examines how Fmr1 knockout rats exhibit behavioral and neural network impairments linked to autism-like symptoms, suggesting that restoring neural dynamics may improve outcomes.

Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures

The paper investigates how ACTH and dexamethasone affect gene expression pathways in rats after early-life seizures, showing ACTH normalizes expression while Dex does not.

Distributed dynamic coding for spatial working memory in hippocampal-prefrontal networks

The paper investigates how spatial working memory is encoded and maintained in the hippocampal-prefrontal network using single-unit recordings in rats, finding altered dynamics in a disease model.

Environmental Enrichment Normalizes Hippocampal Timing Coding in a Malformed Hippocampus

The paper shows environmental enrichment improves cognitive function in rats with hippocampal malformations by restoring abnormal spike timing and rate coding in hippocampal neurons.