Author

Philippe Herbomel

Centre National de la Recherche ScientifiqueORCID 0000-0002-8946-3313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 5

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Organism:zebrafish· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Anne-Lou TouretiD· 3 shared Anne SchmidtiD· 2 shared Catherine Vivier· 2 shared Doris Lou DemyiD· 2 shared Emi MurayamaiD· 2 shared Muriel Tauzin· 2 shared Bas PonsioeniD· 1 shared Chooyoung BaekiD· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersDevelopmental Biology

Anne-Lou TouretORCID

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5 papers

Recent·Most cited

Alcam-a and Pdgfr-α are essential for the development of sclerotome derived stromal cells that support hematopoiesis in vivo.

Emi Murayama, Catherine Vivier, Anne Schmidt, Anne-Lou Touret, Philippe Herbomel

This study identifies Alcam and Pdgfr-α as critical for sclerotome-derived stromal cell development that supports hematopoiesis in zebrafish.

Nature Communications · Mar 1, 2023Peer-reviewedDevelopmental Biology

A dual involvement of Protocadherin-18a in stromal cell development guides the formation of a functional hematopoietic niche.

Anne-Lou Touret, Catherine Vivier, Anne Schmidt, Philippe Herbomel, Emi Murayama

This study shows that Pcdh18a in stromal cell progenitors is essential for hematopoietic niche formation in zebrafish.

Development · Sep 28, 2022Peer-reviewedDevelopmental Biology

Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production

Doris Lou Demy, Anne-Lou Touret, Mylène Lancino, Muriel Tauzin, Lavinia Capuana, Constance Pierre, Philippe Herbomel

The paper shows Trim33 is essential for primitive macrophage lifespan and definitive macrophage production in zebrafish, with effects on neutrophil and thrombocyte production.

Development · Sep 2, 2022Peer-reviewedDevelopmental Biology

Phosphatidylinositol-3 kinase activity controls survival and stemness of zebrafish hematopoietic stem/progenitor cells

Sasja Blokzijl-Franke, Bas Ponsioen, Stefan Schulte‐Merker, Philippe Herbomel, Karima Kissa, Suma Choorapoikayil, Jeroen den Hertog

The paper investigates how PI3K signaling affects survival and stemness of zebrafish HSPCs during EHT, finding that both loss of Pten and PI3K inhibition induce apoptosis, while surviving cells show reduced stemness.

Oncogene · Mar 13, 2021Peer-reviewedDevelopmental Biology

The cationic amino acid exporter Slc7a7 is vital for and induced in tissue macrophages with sustained efferocytic activity

Doris Lou Demy, Mireille Carrère, Ramil R. Noche, Muriel Tauzin, Marion Le Bris, Chooyoung Baek, Malika Yousfi, Ignaty Leshchiner, Wolfram Goessling, Philippe Herbomel

This study shows that Slc7a7 is essential for tissue macrophages with sustained efferocytic activity, as its expression is induced during efferocytosis and supports their survival.

Journal of Cell Science · Sep 24, 2020Peer-reviewedDevelopmental Biology