Wolfram Goessling

This study identifies CD8+TOX+ T-cells as a specific marker for autoimmune hepatitis using single-nucleus RNA sequencing.

This study shows that Bnip3lb-driven mitophagy maintains embryonic HSPC multipotency and expansion by regulating ROS levels, and enhances ex vivo hematopoietic potential of iPSC-derived HSPCs.

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

This paper harmonizes TUNEL with multiplexed immunofluorescence to improve spatial contextualization of cell death in tissues.

This study uses single-nucleus multi-omics to analyze fibrolamellar carcinoma, revealing rewired cell communication and potential therapeutic targets.

This study identifies Osr1's role in maintaining renal progenitors and regulating podocyte development through Wnt2ba expression, revealing its antagonistic relationship with Hand2.

This study shows that Slc7a7 is essential for tissue macrophages with sustained efferocytic activity, as its expression is induced during efferocytosis and supports their survival.

The paper demonstrates the effectiveness of synthetic sgRNAs and dsDNA templates for efficient HDR and genome editing in zebrafish.

This study identifies tfap2a as a key regulator of distal nephron segment differentiation in zebrafish, revealing its role in controlling gene regulatory networks and specialized metabolic functions.

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.