Takashi Yamashiro

IMAS resolves perturbation-sensitive regulatory architectures from matched tumour multiomics

IMAS identifies target-specific regulatory architectures from multiomic tumour data by integrating RNA and chromatin-accessibility profiles to uncover perturbation-sensitive mechanisms.

TMEM2-mediated hyaluronan turnover maintains articular cartilage homeostasis during osteoarthritis progression

This study identifies TMEM2 as a regulator of hyaluronan turnover in articular cartilage, showing its role in maintaining ECM integrity during osteoarthritis progression.

Retinoid signaling promotes frontonasal identity while repressing maxillary identity during craniofacial development

This study shows retinoid signaling specifies frontonasal identity and represses maxillary identity in cranial neural crest cells during facial development in mice.

A Wnt-responsive fibrocartilage progenitor system coordinates postnatal mandibular condylar cartilage growth

The paper identifies a Wnt-responsive fibrocartilage progenitor system that coordinates postnatal mandibular condylar cartilage growth through Foxm1-dependent proliferation and suppression of TGF-β-driven chondrogenic differentiation.

Compromised actin dynamics underlie the orofacial cleft in Baraitser-Winter Cerebrofrontofacial Syndrome with a variant in ACTB

This study identifies a variant in the ACTB gene associated with orofacial clefts in BWCFF and shows it impairs actin dynamics and epithelial cell function.

Filamin A mediates embryonical palatal fusion by linking mechanotransduction with β-Catenin/Smad2

The paper identifies Filamin A's role in palatal fusion by linking mechanotransduction with β-Catenin/Smad2 signaling, showing its impact on cleft palate risk through parental physical activity.

SLC26A2-mediated sulfate metabolism is essential for the tooth development

This study shows that SLC26A2-mediated sulfate metabolism is essential for tooth development, as its deficiency leads to craniofacial abnormalities and tooth hypoplasia in mice.

The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival

This paper shows that TMEM2, a cell surface hyaluronidase, is essential for neural crest cell development and survival in mice, as its absence causes craniofacial and cardiovascular defects.

Intracellular and intercellular gene regulatory networks inference from time-course individual RNA-Seq

The paper infers gene regulatory networks from time-course bulk RNA-Seq data to reveal both intracellular and intercellular regulatory relationships during development.

Anterior Cleft Palate due to Cbfb deficiency and its rescue by folic acid

The paper shows that Cbfb is essential for anterior palatogenesis and that folic acid rescues cleft palate by restoring Stat3 phosphorylation and Tgfb3 expression in vitro.