Yu Yamaguchi

This study identifies TMEM2 as a regulator of hyaluronan turnover in articular cartilage, showing its role in maintaining ECM integrity during osteoarthritis progression.

The paper identifies DNA methylation signatures associated with NSD2 loss-of-function variants and shows their similarity to those in Wolf-Hirschhorn syndrome.

This paper shows that TMEM2, a cell surface hyaluronidase, is essential for neural crest cell development and survival in mice, as its absence causes craniofacial and cardiovascular defects.

This study identifies the versican-hyaluronan complex as essential for vasculogenesis and primitive hematopoiesis by providing a niche for Flk1+ progenitors during gastrulation.