Author

Jacob T. Croft

University of WashingtonORCID 0000-0002-8964-3699Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Kelly K. LeeiD· 3 shared Cynthia A. DerdeyniD· 2 shared Daniel P. LeamaniD· 2 shared Hung Nguyen DoiD· 2 shared Katelyn J. ChaseiD· 2 shared Klaus N. LovendahliD· 2 shared Michael B. ZwickiD· 2 shared Pooja Ralli-Jain· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Kelly K. LeeORCID

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3 papers

Recent·Most cited

Reconstructing a Missing Link of HIV-1 Assembly: HIV-1 Envelope-Matrix Interactions in a Native Viral Context

Jacob T. Croft, Hung Nguyen Do, Daniel P. Leaman, Klaus N. Lovendahl, Pooja Ralli-Jain, Katelyn J. Chase, Cynthia A. Derdeyn, Michael B. Zwick, Sandrasegaram Gnanakaran, Kelly K. Lee

This study investigates HIV-1 Env-MA interactions using cryo-ET and simulations, revealing the Kennedy-sequence motif's role in Env incorporation and Gag maturation's effect on Env clustering.

bioRxiv · Jan 16, 2026 · PreprintBiochemistry

Structure of HIV-1 Env glycoprotein on virions reveals an alternative fusion subunit organization and native membrane coupling

Jacob T. Croft, Hung Nguyen Do, Daniel P. Leaman, Klaus N. Lovendahl, Pooja Ralli-Jain, Katelyn J. Chase, Chengbo Chen, Vidya Mangala Prasad, Cynthia A. Derdeyn, Michael B. Zwick, Sandrasegaram Gnanakaran, Kelly K. Lee

This study reveals conformational differences in HIV-1 Env glycoprotein on virions compared to soluble forms, highlighting the role of the viral membrane in maintaining native structure.

bioRxiv · Jan 10, 2026 · PreprintBiochemistry

Host Switching Mutations in H5N1 Influenza Hemagglutinin Suppress Site-specific Activation Dynamics

Sally M. Kephart, Kiran F. Awatramani, Mason Saunders, Jacob T. Croft, Kelly K. Lee

The paper investigates how adaptive mutations in H5N1 influenza HA affect activation dynamics, showing suppressed fusion peptide dynamics and stabilized subunit interfaces in adapted variants.

Nature Communications · Dec 5, 2025Peer-reviewedBiophysics