Author

Daniel P. Leaman

Scripps Research InstituteORCID 0000-0002-8490-1126Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:microscopy & imaging analysis· 3 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:imaging· 1 Organism:virus· 1

Frequent Co-Authors

Michael B. ZwickiD· 4 shared Andrew B. WardiD· 2 shared Charles Daniel MuriniD· 2 shared Cynthia A. DerdeyniD· 2 shared Emily Margaret MaceiD· 2 shared Hijab Fatima· 2 shared Hung Nguyen DoiD· 2 shared Jacob T. CroftiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

Michael B. ZwickORCID

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4 papers

Recent·Most cited

The membrane distal domain of CD16a allosterically regulates NK cell ADCC

Tania Cid, Monica Fernandez-Quintéro, Hijab Fatima, Ema Robinson, Braden Christenson, Johannes R. Loeffler, Daniel P. Leaman, Ryan Lin, Kayla Xu, Jessica Matthias, Scott C. Henderson, Kathryn Spencer, Joseph Jardine, Michael B. Zwick, Andrew B. Ward, , Charles Daniel Murin

This paper identifies an allosteric checkpoint in CD16a that regulates NK cell ADCC independently of IgG-Fc binding, revealing a mechanism for modulating immune responses.

bioRxiv · Jul 6, 2026 · PreprintImmunology

Reconstructing a Missing Link of HIV-1 Assembly: HIV-1 Envelope-Matrix Interactions in a Native Viral Context

Jacob T. Croft, Hung Nguyen Do, Daniel P. Leaman, Klaus N. Lovendahl, Pooja Ralli-Jain, Katelyn J. Chase, Cynthia A. Derdeyn, Michael B. Zwick, Sandrasegaram Gnanakaran, Kelly K. Lee

This study investigates HIV-1 Env-MA interactions using cryo-ET and simulations, revealing the Kennedy-sequence motif's role in Env incorporation and Gag maturation's effect on Env clustering.

bioRxiv · Jan 16, 2026 · PreprintBiochemistry

Structure of HIV-1 Env glycoprotein on virions reveals an alternative fusion subunit organization and native membrane coupling

Jacob T. Croft, Hung Nguyen Do, Daniel P. Leaman, Klaus N. Lovendahl, Pooja Ralli-Jain, Katelyn J. Chase, Chengbo Chen, Vidya Mangala Prasad, Cynthia A. Derdeyn, Michael B. Zwick, Sandrasegaram Gnanakaran, Kelly K. Lee

This study reveals conformational differences in HIV-1 Env glycoprotein on virions compared to soluble forms, highlighting the role of the viral membrane in maintaining native structure.

bioRxiv · Jan 10, 2026 · PreprintBiochemistry

Spatial localization of CD16a at the human NK cell ADCC lytic synapse

Patrick A. Ross, Tania Cid, Monica Fernández Quintero, Johannes R. Loeffler, Hijab Fatima, Daniel P. Leaman, Jessica Matthias, Kathryn S. R. Spencer, Michael B. Zwick, Scott C. Henderson, Andrew B Ward, Emily Margaret Mace, Charles Daniel Murin

This study uses MINFLUX nanoscopy to map CD16a spatial distribution in NK cells, revealing CD16a pairs and increased density at synapses during ADCC activation.

The Journal of Immunology · Jun 16, 2025Peer-reviewedImmunology