Author

Chengbo Chen

University of WashingtonORCID 0000-0002-3459-3655Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:virus· 2 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Kelly K. LeeiD· 2 shared Klaus N. LovendahliD· 2 shared Adian Valdez· 1 shared Alvaro Molina-CruziD· 1 shared Azza H. IdrisiD· 1 shared Courtney E McDougaliD· 1 shared Cynthia A. DerdeyniD· 1 shared Daniel P. LeamaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

Kelly K. LeeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 7, 2026

Mannosylated nanoparticle immunogens enhance the circumsporozoite protein-specific B cell response and improve protection against sporozoite challenge

Courtney E McDougal, Mark D. Langowski, Daria Nikolaeva…·Neil P. King

This study shows that nanoparticle vaccines with oligomannose glycans boost B cell responses and protection against malaria sporozoites compared to other glycan types.

1 citation

protein sequenceexperimental assay

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BiochemistrybioRxivPreprintJan 10, 2026

Structure of HIV-1 Env glycoprotein on virions reveals an alternative fusion subunit organization and native membrane coupling

Jacob T. Croft, Hung Nguyen Do, Daniel P. Leaman…·Kelly K. Lee

This study reveals conformational differences in HIV-1 Env glycoprotein on virions compared to soluble forms, highlighting the role of the viral membrane in maintaining native structure.

6 citations

viruscryo-EM

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MicrobiologyPLoS PathogensPeer-reviewedSep 22, 2025

Interprotomer Crosstalk in Mosaic Viral Glycoprotein Trimers Provides Insight into Polyvalent Immunogen Co-assembly

Chengbo Chen, Klaus N. Lovendahl, Julie M. Overbaugh, Kelly K. Lee

This study investigates the structural dynamics of mosaic SARS-CoV-2 spike trimers formed by co-assembling different variants, showing preserved stability and antigenicity with potential implications for polyvalent vaccine design.

1 citation

virusproteomics

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