Kelly K. Lee

Cryo-EM mapping of circumsporozoite protein epitope accessibility and visualization of antibody-induced shedding on Plasmodium falciparum sporozoites

This study uses cryo-EM to examine how antibodies against different PfCSP epitopes affect the structure and shedding of the circumsporozoite protein on Plasmodium falciparum sporozoites.

Reconstructing a Missing Link of HIV-1 Assembly: HIV-1 Envelope-Matrix Interactions in a Native Viral Context

This study investigates HIV-1 Env-MA interactions using cryo-ET and simulations, revealing the Kennedy-sequence motif's role in Env incorporation and Gag maturation's effect on Env clustering.

Structure of HIV-1 Env glycoprotein on virions reveals an alternative fusion subunit organization and native membrane coupling

This study reveals conformational differences in HIV-1 Env glycoprotein on virions compared to soluble forms, highlighting the role of the viral membrane in maintaining native structure.

Host Switching Mutations in H5N1 Influenza Hemagglutinin Suppress Site-specific Activation Dynamics

The paper investigates how adaptive mutations in H5N1 influenza HA affect activation dynamics, showing suppressed fusion peptide dynamics and stabilized subunit interfaces in adapted variants.

Tau4RD fibril polymorphism is imprinted during early aggregation

This study uses pulsed HDX-MS to investigate whether tau4RD fibril polymorphism is imprinted during early aggregation or arises from structural rearrangements later in the process.

Interprotomer Crosstalk in Mosaic Viral Glycoprotein Trimers Provides Insight into Polyvalent Immunogen Co-assembly

This study investigates the structural dynamics of mosaic SARS-CoV-2 spike trimers formed by co-assembling different variants, showing preserved stability and antigenicity with potential implications for polyvalent vaccine design.