Paul Schulze‐Lefert

This study shows that XopQ, a bacterial virulence protein, cleaves 2'cADPR to suppress plant TIR immune signaling and promote pathogen virulence.

This paper presents a protocol for purifying recombinant proteins from Nicotiana benthamiana for structural studies, demonstrating its effectiveness for complex purification and cryo-EM analysis.

The paper establishes reproducible methods for plant-microbiome research using fabricated ecosystems across multiple laboratories.

The paper identifies a multigenic QTL in Arabidopsis thaliana that influences root responses to Pseudomonas microbiota, revealing genetic mechanisms linking microbial interaction to root development.

The paper introduces the Darwin21 Genome Database, a curated repository of whole-genome sequences of endophytic bacteria from desert plants, supporting research on microbial ecology and plant resilience.

The paper determines the cryo-EM structure of the MLA13-AVRA13-1 heterodimer and shows how a single amino acid substitution in MLA7 expands effector recognition.

This study identifies Scs6, a barley gene required for susceptibility to the necrotrophic fungus Bipolaris sorokiniana, and shows it is targeted by a non-ribosomal peptide effector.

The paper evaluates metagenomic software tools using realistic datasets, highlighting improvements in assembly and taxon profiling while identifying remaining challenges in virus/archaea detection and reproducibility.

The paper analyzes the genome of Blumeria graminis forma specialis hordei to show retained synteny, copy number variation of secretion peptide genes, and recent transposable element expansion, suggesting a 'one-speed' genome structure.

The paper benchmarks computational metagenomics software using complex datasets, showing strengths and limitations in assembly, binning, and taxonomic profiling.