Author

Alexander Tolkachov

German Cancer Research CenterORCID 0000-0002-8981-9893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ângela GonçalvesiD· 2 shared Duncan T. OdomiD· 2 shared Ivana WinkleriD· 2 shared Klaudija DaugėlaitėiD· 2 shared Marie-Luise KochiD· 2 shared Nina G. SchneideriD· 2 shared Perrine LacouriD· 2 shared Adriana VilkaiteiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenomics

Ângela GonçalvesORCID

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2 papers

Recent·Most cited

The function and decline of the female reproductive tract at single-cell resolution

Ivana Winkler, Alexander Tolkachov, Fritjof Lammers, Perrine Lacour, Klaudija Daugėlaitė, Nina G. Schneider, Marie-Luise Koch, Jasper Panten, Florian Grünschläger, Tanja Poth, Bianca M. Ávila, Augusto Schneider, Simon F. Haas, Duncan T. Odom, Ângela Gonçalves

This study maps the single-cell transcriptional and morphological changes in the mouse female reproductive tract across the estrus cycle, decidualization, and aging, revealing age-related fibrosis and inflammation.

Cell · Feb 1, 2024Peer-reviewedGenomics

Superovulation and aging perturb oocyte-granulosa cell communication

Klaudija Daugėlaitė, Perrine Lacour, Ivana Winkler, Marie-Luise Koch, Anja Schneider, Nina G. Schneider, Alexander Tolkachov, Xuan Phuoc Nguyen, Adriana Vilkaite, Julia Rehnitz, Duncan T. Odom, Ângela Gonçalves

This study investigates how superovulation and aging affect oocyte-granulosa cell communication in mice, finding that both disrupt similar gene sets and impair oocyte quality.

bioRxiv · Oct 30, 2023 · PreprintDevelopmental Biology