This study shows that exosomes from cyclic mice can reverse liver transcriptome changes in estropausal mice, independent of age, by modulating miRNA content.

Molecular and Cellular Endocrinology · Nov 6, 2024Peer-reviewedPhysiology

Effect of senolytic drugs in young female mice chemically induced to estropause

Bianca M. Ávila, Bianka M. Zanini, Karina Pereira Luduvico, Thaís Larré Oliveira, Jéssica D. Hense, Driele Neske Garcia, Juliane B. Prosczek, Francieli Moro Stefanello, Pedro Henrique Flores Da Cruz, Janice Luehring Giongo, Rodrigo de Almeida Vaucher, Jeffrey B. Mason, Michał M. Masternak, Augusto Schneider

This study examines metabolic changes and senescent cell burden in young female mice with induced estropause, finding minor metabolic effects and no protective effect of senolytic drugs.

Life Sciences · Sep 20, 2024Peer-reviewedPhysiology

The function and decline of the female reproductive tract at single-cell resolution

Ivana Winkler, Alexander Tolkachov, Fritjof Lammers, Perrine Lacour, Klaudija Daugėlaitė, Nina G. Schneider, Marie-Luise Koch, Jasper Panten, Florian Grünschläger, Tanja Poth, Bianca M. Ávila, Augusto Schneider, Simon F. Haas, Duncan T. Odom, Ângela Gonçalves

This study maps the single-cell transcriptional and morphological changes in the mouse female reproductive tract across the estrus cycle, decidualization, and aging, revealing age-related fibrosis and inflammation.

Cell · Feb 1, 2024Peer-reviewedGenomics