Author
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)ORCID 0000-0002-8443-0192Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Aleix Puig-Barbe, Svenja Dettmann, Vinícius Dias Nirello, Helen Moor, Sina Azami, Bruce A. Edgar, Patrick Varga‐Weisz, Jerome Korzelius, Joaquín de Navascués
The paper shows that bHLH transcription factor interactions regulate stemness and bipotential differentiation in Drosophila gut stem cells.
Cell Reports · Mar 1, 2025Peer-reviewedDevelopmental Biology
E. KING, Eleanor Jacobsen, Nicholas Woolner, Joaquín de Navascués, Owen J. Marshall, Jerome Korzelius
This study identifies the transcription factor Cph as promoting intestinal stem cell proliferation and endocrine differentiation in Drosophila, with implications for tumorigenesis and aging.
bioRxiv · Aug 5, 2024 · PreprintDevelopmental Biology
Ewart Kuijk, Myrthe Jager, Bastiaan R. Van der Roest, Mauro D. Locati, Arne van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle J.M. Besselink, Sander Boymans, Ruben van Boxtel, Edwin P. J. G. Cuppen
This study quantifies and characterizes mutation accumulation in human induced pluripotent stem cells and adult stem cells during in vitro culture, revealing distinct mutational signatures and higher mutation rates compared to in vivo.
Nature Communications · May 19, 2020Peer-reviewedGenomics
Sjors Middelkamp, Judith M. Vlaar, Jacques C. Giltay, Jerome Korzelius, Nicolle J.M. Besselink, Sander Boymans, Roel Janssen, Lisanne de la Fonteijne, Ellen van Binsbergen, Markus J. van Roosmalen, Ron Hochstenbach, Daniela Francesca Giachino, Michael E. Talkowski, Wigard P. Kloosterman, Edwin P. J. G. Cuppen
This study prioritizes driver genes in patients with de novo genomic structural variants using integrative analysis of WGS data, phenotype information, and chromatin organization datasets.
Genome Medicine · Dec 1, 2019Peer-reviewedGenomics
Jerome Korzelius, Sina Azami, Tal Ronnen-Oron, Philipp Koch, Maik Baldauf, Elke Meier, Imilce A. Rodriguez‐Fernandez, Marco Groth, Pedro Sousa‐Victor, Heinrich Jasper
The paper identifies Klumpfuss as a transcription factor that restricts enteroblast fate to enterocytes in Drosophila via Notch signaling.
Nature Communications · Sep 11, 2019Peer-reviewedDevelopmental Biology
Mircea Cretu-Stancu, Markus J. van Roosmalen, Ivo Renkens, Marleen M. Nieboer, Sjors Middelkamp, Joep de Ligt, Giulia Pregno, Daniela Francesca Giachino, Giorgia Mandrile, Jose Espejo Valle-Inclán, Jerome Korzelius, Ewart de Bruijn, Edwin P. J. G. Cuppen, Michael E. Talkowski, Tobias Marschall, , Wigard P. Kloosterman
This study uses nanopore sequencing to detect and phase structural variants in patient genomes, identifying novel variants missed by short-read sequencing.
Nature Communications · Oct 31, 2017Peer-reviewedGenomics