Rurika Oka

The paper introduces an updated R/Bioconductor package for analyzing mutational patterns, demonstrating its ability to detect mutational signatures and their biological implications using simulated and real data.

This study evaluates prime editing for modeling cancer mutations and repairing CFTR in intestinal organoids, showing its potential but also highlighting challenges in efficiency and off-target effects.

This paper demonstrates the use of prime editing to correct genetic mutations in patient-derived organoids, showing high efficiency and precision with minimal off-target effects.