Tarek Z. Deeb

This study isolates and characterizes multi-protein complexes containing Kcc2 from brain plasma membranes, identifying novel interactors and phosphorylation sites that may regulate its function.

The paper identifies KCC2 as a convergence point for ASD/Epi risk genes through proteomic analysis and shows its interaction with FMRP targets and effects on GABAergic inhibition.

This study uses MEA assays to show that L-type calcium channel inhibitors affect synchronous firing in hiPSC-derived neuronal networks, suggesting their utility for studying psychiatric risk genes.