Genome-wide CRISPR Screening Reveals Cullin-1 as a Therapeutic Target Enhancing Efficacy of CD19-directed Immunotherapy
Narendra Varma Gottumukkala, Tomáš Loja, Michal Šmída
This study identifies Cullin-1 as a target to enhance CD19-directed immunotherapy by preventing CD19 downregulation through inhibition with pevonedistat.