Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion
Sébastien Houy, Joana S Martins, Noa Lipstein, Jakob Balslev Sørensen
The paper investigates the opposing roles of Munc13-1 and ubMunc13-2 in dense-core vesicle secretion in response to phorbolesters, showing that ubMunc13-2 promotes secretion while Munc13-1 inhibits it, with syt7 mediating the stimulatory effect of phorbolesters.