Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity
Erica Maria Pimenta, Amanda Garza, Sabrina Yvonne Camp, Jihye Park, Samantha E. Hoffman, Laura Valderrábano, Jingxin Fu, Kevin Bi, Maximilian Carson, Julie Karam, Breanna M. Titchen, Sofia Medjahed, Melin Janardan Khandekar, Erin E. Shannon, Yun Jee Kang, , Eliezer M. Van Allen
This study identifies epigenetic dysregulation of metabolic programs in liposarcoma, linking IGF1 loss and PPARG2 deficiency to dedifferentiation and proposing IGF1R-targeted therapy.
Science Translational Medicine · Jan 21, 2026Peer-reviewedCancer Biology