Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies
Alexandra A. M. Fischer, Martin Corcoran, Philip J. M. Brouwer, Mark Chernyshev, Rebecca A. Gillespie, Andrea Nicoletto, Johannes R. Loeffler, James A. Ferguson, Alesandra J. Rodriguez, Sanjana Narang, Marit J. van Gils, Xaquín Castro Dopico, Masaru Kanekiyo, Andrew B. Ward, Julianna Han, Gunilla B. Karlsson Hedestam
The paper shows that genetic variation in human immunoglobulin genes affects antibody responses to influenza HA, informing vaccine design to cover diverse populations.
bioRxiv · Jul 4, 2025 · PreprintImmunology